profile
Dr. Kalyan Sundar Ghosh
Assistant Professor (Gr-I)Dr. Kalyan Sundar Ghosh is presently working as an Assistant Professor (Grade-I) in the Department of Chemistry, National Institute of Technology Hamirpur, Himachal Pradesh, India. Dr. Ghosh had pursued his doctoral research at Department of Chemistry, IIT Kharagpur (Jan 2004 - Jan 2009) under supervision of Prof. Swagata Dasgupta. Then he had worked as Postdoctoral Associate in University of Maryland, College Park, USA and State University of New York, Albany, USA in a broad area of protein chemistry. He has more than 50 publications in indexed journals of repute. Some of his publications had crossed more than hundred citations each. His research interests broadly include Design and development of chemo and biosensors, bioorganic and biophysical chemistry, nano and bionanomaterials and their applications. Scopous id: 7201768633
General Information
| Name | : | Dr. Kalyan Sundar Ghosh |
| Designation | : | Assistant Professor (Gr-I) |
| Department | : | Chemistry |
| Qualification | : | Ph.D. |
| Date of Birth | : | 04/29/1982 |
| Date of joining | : | 05/03/2012 |
Contact Details
| Phone | : | 01972-254104 |
| Email ID | : | kalyan@nith.ac.in |
Specialization
Position Held
| Position | Department Name | Institute Name | Time Period |
|---|
Educational Qualification
| Name of the Degree | Year of Passing | Institute/University |
|---|---|---|
| Ph.D | 2009 | IIT Kharagpur |
| M.Sc. | 2003 | University of Calcutta |
| B.Sc. (Hons) in Chemistry | 2001 | Presidency College, University of Calcutta |
Honors & Recognitions Achieved
| Sr.No. | Title | Activity | Given By | Year |
|---|
Research Experience
| Research Interests : | Bioorganic Chemistry, Biophysical Chemistry, Nanomaterials | |
| Brief Research Statement : | 1. Design and development of chemical and biochemical sensors 2. Studies on the interactions between small molecules and biomacromolecules 3. Protein aggregation and its inhibition by using small molecules (synthetic and natural) and specifically designed nanomaterials |
Journal Publications
| Year | Author(s) | Title & Vol. No. | Journal Name | Indexing (SCI) Web of Science/Scopus |
|---|---|---|---|---|
| 2018 | Dolai, B., Bhaumik, A., Pramanik, N., Ghosh, K. S., Atta, A. K. | Naphthaldimine-based simple glucose derivative as a highly selective sensor for colorimetric detection of Cu2+ ion in aqueous media | J. Mol. Structure (Impact factor: 3.20) | SCI & Scopus |
| 2018 | Babu, M. S., Reddy, K. S., Ghosh, K. S., Sahoo, B. K., Himasekar, Ch., Mustafa, S. | Design, Synthesis, Single X-Ray Crystal Structure, DFT and Molecular Docking Studies of Novel Clip Type-Pyridyltetrazole Analogues | Asian J. Chem. | Scopus |
| 2018 | Rana, N., Ghosh, K. S., Chand, S., Gathania, A. K. | Investigation of ZnO nanoparticles for their applications in wastewater treatment and antimicrobial activity | Ind. J. Pure Appl. Phys. (Impact factor: 0.92) | SCI (E) |
| 2017 | Sharma, V., Ghosh, K. S. | Inhibition of amyloid fibrillation and destabilization of fibrils of human ?D-crystallin by direct red 80 and orange G | Intl. J. Biol. Macromol. (Impact factor: 6.95) | SCI (E) & Scopus |
| 2017 | Chauhan, P., Velappan, A. B., Sahoo, B. K., Debnath, J., Ghosh, K. S. | Studies on molecular interactions between Schiff bases and eye lens chaperone human ?A-crystallin | J. Lumin. (Impact factor: 3.60) | SCI & Scopus |
| 2017 | Chauhan, P., Muralidharan, S. B., Velappan, A. B., Datta, D., Pratihar, S., Debnath, J., Ghosh, K. S. | Inhibition of copper-mediated aggregation of human ?D-crsytallin by Schiff bases | J. Biol. Inorg. Chem. (Impact factor: 3.36) | SCI & Scopus |
| 2016 | Sivaramakrishnan, V., Ilamathi, M., Ghosh, K. S., Sathish, S., Gowda, T. V., Vishwanath, B. S., Rangappa, K. S., Dhananjaya, B. L. | Virtual analysis of structurally diverse synthetic analogs as inhibitors of snake venom secretory phospholipase A2 | J. Mol. Recognit. (Impact factor: 2.14) | SCI & Scopus |
| 2015 | Thakur, R., Das, A., Sharma, V., Adhikari, C., Ghosh, K.S., Chakraborty, A. | Interaction of different prototropic species of an anticancer drug Ellipticine with HSA and IgG proteins: multispectroscopic and molecular modeling studies | Phy. Chem. Chem. Phys. (Impact factor: 3.68) | Web of Science |
| 2015 | Sharma, A., Ghosh, K. S., Singh, B. P., Gathania, A. K. | Spectroscopic investigation of interaction between bovine gamma globulin and gold nanoparticles | Methods Appl. Fluoresc. (Impact factor: 3.01) | SCI & Scopus |
| 2014 | Sharma, V., Ghosh, K. S. | Involvement of non-polyalanine (polyA) residues in aggregation of polyA proteins: Clue for inhibition of aggregation | Comp. Biol. Chem. (Impact factor: 2.88) | SCI & Scopus |
| 2013 | Ghosh, K. S. | Inherent aggregation propensity of flanking residues attached to polyglutamines: implication to aggregation inhibition | Prot. Pept. Lett. (Impact factor: 1.89) | SCI (E) & Scopus |
| 2013 | Roy, A. S., Ghosh, K. S., Dasgupta, S. | An investigation into the altered binding mode of green tea polyphenols with human serum albumin on complexation with copper | J. Biomol. Struct. Dyn. (Impact factor: 3.39) | SCI (E) & Scopus |
| 2012 | Roy, D., Dutta, S., Maity, S. S., Ghosh, S., Roy, A. S., Ghosh, K. S., Dasgupta, S. | Spectroscopic and docking studies of the binding of two stereoisomeric antioxidant catechins to serum albumins | J. Lumin. (Impact factor: 3.60) | SCI & Scopus |
| 2011 | Ghosh, K. S., Pande, A., Pande, J. | Binding of gamma crystallin substrate prevents the binding of copper and zinc ions to the molecular chaperone alpha crystallin | Biochemistry (Impact factor: 3.16) | SCI & Scopus |
| 2010 | Pande, A., Ghosh, K. S., Banerjee, P. R., Pande, J. | Increase in surface hydrophobicity of the cataract-associated, P23T mutant of human gammaD-crystallin is responsible for its dramatically lower, retrograde solubility | Biochemistry (Impact factor: 3.16) | SCI & Scopus |
| 2010 | Chandra, G., Ghosh, K. S., Dasgupta, S., Roy, A. | Evidence of conformational changes in adsorbed lysozyme molecule on silver colloids | Intl. J. Biol. Macromol. (Impact factor: 6.95) | SCI (E) & Scopus |
| 2010 | Mukhopadhyay, S., Maity, S. S., Roy, A., Chattopadhyay, D., Ghosh, K. S., Dasgupta, S., Ghosh, S. | Characterization of the structure of the phosphoprotein of chandipura virus, a negative stranded RNA virus probing intratryptophan energy transfer using single and double tryptophan mutants | Biochimie (Impact factor: 4.08) | SCI & Scopus |
| 2009 | Sahoo, B. K., Ghosh, K. S., Dasgupta, S. | An Investigation of the molecular interactions of diacetylcurcumin with ribonuclease A | Prot. Pept. Lett. (Impact factor: 1.89) | SCI (E) & Scopus |
| 2009 | Ghosh, K. S., Sen, S., Sahoo, B. K., Dasgupta, S. | A spectroscopic investigation into the interactions of 3´-O-carboxy esters of thymidine with Bovine Serum Albumin | Bioploymers (Impact factor: 2.51) | SCI & Scopus |
| 2009 | Sahoo, B. K., Ghosh, K. S., Dasgupta, S. | Molecular interactions of isoxazolcurcumin with human serum albumin: spectroscopic and molecular modeling studies | Bioploymers (Impact factor: 2.51) | SCI & Scopus |
| 2008 | Ghosh, K. S., Debnath, J., Pathak, T., Dasgupta, S. | Using Proton Nuclear Magnetic Resonance to study the mode of Ribonuclease A inhibition by competitive and noncompetitive inhibitors | Bioorg. Med. Chem. Lett. (Impact factor: 2.82) | SCI & Scopus |
| 2008 | Ghosh, K. S., Sahoo, B.K., Jana, D., Dasgupta, S. | Studies on interaction of copper complexes of (-)-epicatechin gallate and (-)-epigallocatechin gallate with calf thymus DNA | J. Inorg. Biochem. (Impact factor: 4.16) | SCI (E) & Scopus |
| 2008 | Sahoo, B.K., Ghosh, K. S., Dasgupta, S. | Studies on the interaction of diacetylcurcumin with calf thymus DNA | Chem. Phys. (Impact factor: 2.35) | SCI (E) & Scopus |
| 2008 | Ghosh, K. S., Debnath, J., Dutta, P., Sahoo, B. K., Dasgupta, S. | Exploring the potential of 3´-O-Carboxy esters of thymidine as inhibitors of ribonuclease A and angiogenin | Bioorg. Med. Chem. (Impact factor: 3.64) | SCI & Scopus |
| 2008 | Ghosh, K. S., Sahoo, B. K., Dasgupta, S. | Spectrophotometric studies on the interaction between (-)-epigallocatechin gallate and lysozyme | Chem. Phys. Lett. (Impact factor: 2.33) | SCI |
| 2008 | Sahoo, B. K., Ghosh, K. S., Dasgupta, S. | Investigating the binding of curcumin derivatives to bovine serum albumin | Biophys. Chem. (Impact factor: 2.35) | SCI (E) & Scopus |
| 2008 | Bera, R., Sahoo, B. K., Ghosh, K. S., Dasgupta S. (2008) | Studies on the interaction of isoxazolcurcumin with calf thymus DNA | Int. J. Biol. Macromol. (Impact factor: 6.95) | SCI (E) & Scopus |
| 2008 | Maiti, T. K., Ghosh, K. S., Samanta A., Dasgupta S. | The interaction of silibinin with human serum albumin: a spectroscopic investigation | J. Photochem. Photobiol. A (Impact factor: 4.29) | SCI & Scopus |
| 2007 | Mandal, C., Gayen, S., Basu, A., Ghosh, K. S., Dasgupta, S., Maiti, M., Sen, S. | Prediction based protein engineering of domain I of Cry2A entomocidal toxin of Bacillus thuringiensis resulted enhancement of toxicity against lepidopteran insects | Protein Eng. Des. Sel. (Impact factor: 1.77) | SCI |
| 2007 | Ghosh, K. S., Maiti, T.K., Debnath, J., Dasgupta, S. | Inhibition of ribonuclease A by polyphenols present in green tea | Proteins : Structure, Functions & Bioinformatics (Impact factor: 3.76) | SCI & Scopus |
| 2006 | Ghosh, K. S., Maiti, T.K., Mandal, A., Dasgupta, S. | Copper complexes of (?)-epicatechin gallate and (?)-epigallocatechin gallate act as inhibitors of ribonuclease A | FEBS Lett. (Impact factor: 4.12) | SCI |
| 2006 | Maiti, T. K., Ghosh, K. S., Dasgupta, S. | Interaction of (-)-epigallocatechin-3-gallate with human serum albumin: fluorescence, fourier transform infrared, circular dichroism and docking studies | Proteins: Structure, Functions & Bioinformatics (Impact factor: 3.76) | SCI & Scopus |
| 2006 | Maiti, T. K., Ghosh, K. S., Debnath, J., Dasgupta, S. | Binding of all-trans retinoic acid to human serum albumin: fluorescence, FT-IR and circular dichroism studies | Int. J. Biol. Macromol. (Impact factor: 6.95) | SCI (E) & Scopus |
| 2004 | Ghosh, K. S., Maiti, T. K., Dasgupta, S. | Green tea polyphenols as inhibitors of ribonuclease A | Biochem. Biophys. Res. Commun. (Impact factor: 3.58) | SCI & Scopus |
| 2019 | Sharma, V. and Ghosh, K. S. | Inhibition of amyloid fibrillation by small molecules and nanomaterials: strategic development of pharmaceuticals against amyloidosis, Vol. 26, pp. 315 – 323. | Prot. Pept. Lett. (Impact factor: 1.89) | SCI (E) & Scopus |
| 2019 | Chauhan, P. and Ghosh, K. S. | Inhibition of copper-induced aggregation of human gammaD-crystallin by rutin and studies on its role in molecular level for enhancing the chaperone activity of human ?A-crystallin by using multi-spectroscopic techniques, Vol. 218, pp. 229-236. | Spectrochim. Acta A (Impact factor: 4.10) | SCI & Scopus |
| 2020 | S. Rana, A. B. Velappan, J. Debnath, K. S. Ghosh | Inhibition of copper-induced aggregation of human gammaD-crystallin by a diimine molecule and investigations on their molecular interactions | J. Biomol. Strcture Dynamics (Impact factor: 3.39) | SCI (E) & Scopus |
| 2020 | S. Rana and K. S. Ghosh | Protective role of hesperetin against posttranslational oxidation of tryptophan residue of human ?D-crystallin: A molecular level study | Archives of Biochemistry and Biophysics (Impact factor: 4.01) | SCI |
| 2020 | Rana, S., K.S. Ghosh | Explication of human gammaD-crystallin interactions with its aggregation inhibitor Schiff base at molecular level | J. Mol. Struct. (Impact factor: 3.20) | SCI & Scopus |
| 2021 | Rana, S., K.S. Ghosh | Inhibition of fibrillation of human gammaD-crystallin by a flavonoid morin | J. Biomol. Strcture Dynamics (Impact factor: 3.39) | SCI (E) & Scopus |
| 2021 | Rana, S., Sarmah, S., Roy, A. S., Ghosh, K. S. | Elucidation of molecular interactions between human gammaD-crystallin and quercetin, an inhibitor against tryptophan oxidation | J. Biomol. Strcture Dynamics (Impact factor: 3.39) | SCI (E) & Scopus |
| 2020 | Sharma, V., Sharma, S., Rana, S., Ghosh, K. S. | Inhibition of amyloid fibrillation of human gammaD-crystallin by gold nanoparticles: Studies at molecular level | Spectrochimica Acta A (Impact factor: 4.10) | SCI & Scopus |
| 2020 | Sharma, A., Ghosh, K. S. | Studies on molecular interactions between bovine beta-lactoglobulin and silver nanoparticles | Prot. Pept. Lett. (Impact factor: 1.89) | SCI (E) & Scopus |
| 2020 | Velappan, A.B., Datta, D., Ma, R. Rana, S., Ghosh, K.S., Hari, N., Franzblau, S.G., Debnath, J. | 2-Aryl benzazole derived new class of anti-tubercular compounds: Endowed to eradicate Mycobacterium tuberculosis in replicating and non-replicating forms | Bioorg. Chem. (Impact factor: 5.28) | SCI |
| 2021 | S. Rana, M. Panwar, K. S. Ghosh | Docking studies with multiple molecular targets associated with SARSCoV-2 for drug repurposing | Coronaviruses | -- |
| 2021 | Sharma, S., K.S. Ghosh | Recent advances (2017-20) in the detection of copper ion by using fluorescence sensors working through transfer of photo-induced electron (PET), excited-state intramolecular proton (ESIPT) and Förster resonance energy (FRET) | Spectrochimica Acta A (Impact factor: 4.10) | SCI & Scopus |
| 2021 | Sharma, S., K.S. Ghosh | Overview on recently reported fluorometric sensors for the detection of copper ion based on internal charge transfer (ICT), paramagnetic effect and aggregation induced emission (AIE) mechanisms | J. Mol. Struct. (Impact factor: 3.20) | SCI & Scopus |
| 2021 | S. Rana, P. Kumar, A. Sharma, S. Sharma, R. Giri , K. S. Ghosh | Identification of naturally occurring antiviral molecules for SARS-CoV-2 mitigation | The Open COVID Journal | ---- |
| 2022 | A. Sharma, H. Rastogi, K. S. Ghosh | Enhancement in chaperone activity of human aA-crystallin by nanochaperone gold nanoparticles: Multispectroscopic studies on their molecular interactions | Spectrochimica Acta A (Impact factor: 4.10) | SCI & Scopus |
| 2022 | A. Sharma, S. Sarmah, A. S. Roy, K. S. Ghosh | Multispectroscopic studies on the molecular interactions between bovine gamma-globulin and borohydride-capped silver nanoparticles | Luminescence (Impact Factor 2.46) | SCI & Scopus |
Conference Publications
| Year | Author(s) | Title | Conference name with place | Indexing (SCI/Web of science/Scopus) |
|---|
Research Projects
| Role | Project Type | Title | Funding Agency | From | To | Amount | Status | Co-Investigator | Sanction Order | Sanction Date |
|---|---|---|---|---|---|---|---|---|---|---|
| PI | Sponsored | Inhibition of fibrillation of beta and gamma-crystallins: an alternate way against cataract | SERB-DST, GoI | 04/07/2013 | 03/07/2016 | 24.0 lakhs | Completed | NIL | SB/FT/LS-277/2012 | 02/05/2013 |
| PI | Sponsored | Development of Multifunctional Bio-nanomaterial Media for Treatment of Water and Wastewater | TEQIP-II, NIT Hamirpur | 20/03/2014 | 31/03/2015 | 15 lakhs | Completed | NIL | NIT/HMR/TEQIP-II/Research & Development-19/2014/550-56 | 20/03/2014 |
Research Supervision
| Programme Name | Scholar Name | Research Topic | Status | Year | Co-Suprivisor(s) |
|---|---|---|---|---|---|
| Ph.D | Priyanka Chauhan | Schiff Bases and Flavonoids as Inhibitors of Human ?D-crystallin Aggregation and their Interactions with Human ?A-crystallin: An Approach to Impede Cataract | Degree Awarded | 2013 | NIL |
| Ph.D | Vandna Sharma | Studies on Fibrillation of Human gammaD-Crystallin and its Inhibition by using Small Molecules and Nanoparticles | Degree Awarded | 2014 | NIL |
| Ph.D | Shiwani Rana | Inhibition of posttranslational modifications and amyloid fibrillation of human gammaD-crystallin | Degree Awarded | 2016 | NIL |
| Ph.D | Anchal Sharma | Inhibition of protein fibrillation by nanomaterails and studies on interactions between biomacromolecules and nanomaterials | Thesis Submitted | 2017 | NIL |
| Ph.D | Shivani Sharma | Synthesis & development of fluorescence sensors for detection of cations | In progress (State of Art completed) | 2018 | NIL |
| M.Tech | Sristhi Verma (M.Sc.) | Protein chemistry | Completed | 2019 | NIL |
| M.Tech | Sheetal (M.Sc.) | Protein chemistry | Completed | 2019 | NIL |
| M.Tech | Subham Sharma (M.Sc) | Bionanochemistry | Completed | 2019 | NIL |
| M.Tech | Arvind (M.Sc) | Bionanochemistry | Completed | 2019 | NIL |
| M.Tech | Sakshi (M.Sc.) | Synthesis & development of metal sensors | Completed | 2020 | NIL |
| M.Tech | Neha (M.Sc.) | Synthesis & development of metal sensors | Completed | 2020 | NIL |
| M.Tech | Yogesh Routela (M.Sc.) | Synthesis of Schiff base molecules | Completed | 2021 | NIL |
| M.Tech | Abhijit Bhagat (M.Sc.) | Synthesis of Schiff base molecules | Completed | 2021 | NIL |
| M.Tech | Meghali (M.Sc.) | Synthesis of Schiff base molecules | Completed | 2021 | NIL |
| M.Tech | Shivanand (M.Sc.) | Synthesis of Schiff base molecules | Completed | 2021 | NIL |
| M.Tech | Divya Yadav (M.Sc.) | Synthesis of Schiff base sensor | Ongoing | 2022 | NIL |
| M.Tech | Adarsh Porwal (M.Sc.) | Development of metal ion sensor | Ongoing | 2022 | NIL |
| M.Tech | Sachin Kumar (M.Sc.) | Development of metal ion sensor | Ongoing | 2022 | NIL |
| M.Tech | Saurin Maity (M.Sc.) | Design and development of nanosensor | Ongoing | 2022 | NIL |
| Ph.D | Sushma | Design and development of nanomaterials in sensing applications | Ongoing | 2021 | NIL |
| Ph.D | Ankita Sharma | Design & Development of ion sensors | Ongoing | 2022 | NIL |
Patents
| Title | Reg./Ref.No. | Date of Award/Filling | Awarding Agencies | Status |
|---|
Teaching Experience
| Position Held | Department and Organization | From | To | Total Experience |
|---|---|---|---|---|
| Assistant Professor | Dept. of Chemistry, NIT Hamirpur | 03/05/2012 | 8 yrs 4 months (Till date) | |
| Senior Assistant Professor | School of Chemical and Biotechnology, SASTRA University, Tamil Nadu | 22/11/2011 | 30/04/2012 | 5 months |
Administrative Experience
| Position Held | Department and Organization | From | To |
|---|---|---|---|
| Assistant Warden | Kailash Boys Hostel, NIT Hamirpur | 24/06/2013 | 27/07/2015 |
| Assistant Warden | Kailash Boys Hostel, NIT Hamirpur | 28/07/2017 | 25/03/2019 |
| Warden | Kailash Boys Hostel, NIT Hamirpur | 01/06/2020 | 02/03/2022 |
| Warden | Neelkanth Boys Hostel, NIT Hamirpur | 08/08/2020 | 08/02/2021 |
| Warden | Satpura Hostel, NIT Hamirpur | 08/08/2020 | 08/02/2021 |
| Warden | Vindhyachal Boys Hostel, NIT Hamirpur | 08/08/2020 | 22/10/2020 |
| Warden | Dhauladhar Boys Hostel, NIT Hamirpur | 08/08/2020 | 22/10/2020 |
| Warden | Satpura Hostel, NIT Hamirpur | 25/03/2021 | 03/03/2022 |
| Member, NIRF Cell | NIT Hamirpur | 20/09/2021 | |
| Warden | Himadri Hostel, NIT Hamirpur | 03/03/2022 | |
| Faculty Incharge, International & National Ranking (except NIRF & ARIIA) | NIT Hamirpur | 05/04/2022 |
Book/Chapters Written
| Type | Title | Publisher | Author(s) | ISBN/ISSN No. | Year |
|---|---|---|---|---|---|
| Book Chapter | Crystallins and their complexes | Springer | K. S. Ghosh and P. Chauhan | 978-3-030-28151-9 | 2020 |
| Book Chapter | Fluorescent nanomaterials for cellular imaging | IntechOpen | K. S. Ghosh and A. Sharma | 978-1-83968-040-3 | 2020 |
Expert Talks
| Title | Place | Year | Description of Event |
|---|---|---|---|
| Invited Talk | Indira Gandhi National Tribal University, Amarkantak (A Central University) | 2015 | National Workshop cum Seminar on “Frontiers in Ethnomedicinal Research” |
Consultancy
| Title of Consultancy | Client Organization | Faculty Involved | Amount(INR) | Status |
|---|
International and National Exposure
| Sr.No. | Title | Description |
|---|---|---|
| 1 | Postdoctoral Associate | State University of New York, Albany |
| 2 | Postdoctoral Associate | University of Maryland, College Park |
Conferences/Courses Organized
| Category | Type | Title | Venue | From | To | Designation |
|---|---|---|---|---|---|---|
| conference | National | Recent Trends in Chemical Sciences, Engineering and Technology (RTCET 2014) | NIT Hamirpur | 29/05/2014 | 30/05/2014 | Co-Convener |
| stc | GIAN Course | Advanced Nanomaterials: Applications in Disease Diagnosis and Imaging | NIT Hamirpur | 30/05/2016 | 03/06/2016 | Coordinator |
| stc | GIAN Course | Chemical, Biochemical and Environmental Issues Related to Cancer and Solutions Addressing Problems | NIT Hamirpur | 11/09/2017 | 16/09/2017 | Coordinator |
| conference | National | Recent Trends in Chemical Sciences & Engineering (RTCSE - 2017) | NIT Hamirpur | 13/10/2017 | 14/10/2017 | Organizing Secretary |
| workshop | National | Recent Advances in Characterization of Multi-functional Materials | NIT Hamirpur | 17/02/2020 | 22/02/2020 | Convener |
Profile Summary
Last Update: 01/12/2022 12:02am
| Name | : | Dr. Kalyan Sundar Ghosh |
| Designation | : | Assistant Professor (Gr-I) |
| Department | : | Chemistry |
| Qualification | : | Ph.D. |
| Phone | : | 01972-254104 |
| Email ID | : | kalyan@nith.ac.in |
| Profile URL | : | https://portfolios.nith.ac.in/index.php?/nith/dr-kalyan-sundar-ghosh- |
| Date of Birth | : | 04/29/1982 |
| Date of Joining | : | 05/03/2012 |
Specialization
Bioorganic and Biophysical Chemistry
Education Qualification
| Name of the Degree | Year of Passing | Institute/University |
|---|---|---|
| Ph.D | 2009 | IIT Kharagpur |
| M.Sc. | 2003 | University of Calcutta |
| B.Sc. (Hons) in Chemistry | 2001 | Presidency College, University of Calcutta |
Teaching Experience
| Programme Name | Department And Organization | From | To | Total Experience |
|---|---|---|---|---|
| Assistant Professor | Dept. of Chemistry, NIT Hamirpur | 03/05/2012 | 8 yrs 4 months (Till date) | |
| Senior Assistant Professor | School of Chemical and Biotechnology, SASTRA University, Tamil Nadu | 22/11/2011 | 30/04/2012 | 5 months |
Administrative Experience
| Position Held | Department And Organization | From | To |
|---|---|---|---|
| Assistant Warden | Kailash Boys Hostel, NIT Hamirpur | 24/06/2013 | 27/07/2015 |
| Assistant Warden | Kailash Boys Hostel, NIT Hamirpur | 28/07/2017 | 25/03/2019 |
| Warden | Kailash Boys Hostel, NIT Hamirpur | 01/06/2020 | 02/03/2022 |
| Warden | Neelkanth Boys Hostel, NIT Hamirpur | 08/08/2020 | 08/02/2021 |
| Warden | Satpura Hostel, NIT Hamirpur | 08/08/2020 | 08/02/2021 |
| Warden | Vindhyachal Boys Hostel, NIT Hamirpur | 08/08/2020 | 22/10/2020 |
| Warden | Dhauladhar Boys Hostel, NIT Hamirpur | 08/08/2020 | 22/10/2020 |
| Warden | Satpura Hostel, NIT Hamirpur | 25/03/2021 | 03/03/2022 |
| Member, NIRF Cell | NIT Hamirpur | 20/09/2021 | |
| Warden | Himadri Hostel, NIT Hamirpur | 03/03/2022 | |
| Faculty Incharge, International & National Ranking (except NIRF & ARIIA) | NIT Hamirpur | 05/04/2022 |
Research Experience
| Research Interests : | Bioorganic Chemistry, Biophysical Chemistry, Nanomaterials | |
| Brief Research Statement : | 1. Design and development of chemical and biochemical sensors 2. Studies on the interactions between small molecules and biomacromolecules 3. Protein aggregation and its inhibition by using small molecules (synthetic and natural) and specifically designed nanomaterials |
Research Projects
| Role | Project Type | Title | Funding Agency | From | To | Amount | Status | Co-Investigator | Sanction Order | Sanction Date |
|---|---|---|---|---|---|---|---|---|---|---|
| PI | Sponsored | Inhibition of fibrillation of beta and gamma-crystallins: an alternate way against cataract | SERB-DST, GoI | 04/07/2013 | 03/07/2016 | 24.0 lakhs | Completed | NIL | SB/FT/LS-277/2012 | 02/05/2013 |
| PI | Sponsored | Development of Multifunctional Bio-nanomaterial Media for Treatment of Water and Wastewater | TEQIP-II, NIT Hamirpur | 20/03/2014 | 31/03/2015 | 15 lakhs | Completed | NIL | NIT/HMR/TEQIP-II/Research & Development-19/2014/550-56 | 20/03/2014 |
Journal Publications
| Year | Author(s) | Journal Name | Title & Vol. No. | Indexing (SCI/Web of science/Scopus) |
|---|---|---|---|---|
| 2018 | Dolai, B., Bhaumik, A., Pramanik, N., Ghosh, K. S., Atta, A. K. | J. Mol. Structure (Impact factor: 3.20) | Naphthaldimine-based simple glucose derivative as a highly selective sensor for colorimetric detection of Cu2+ ion in aqueous media | SCI & Scopus |
| 2018 | Babu, M. S., Reddy, K. S., Ghosh, K. S., Sahoo, B. K., Himasekar, Ch., Mustafa, S. | Asian J. Chem. | Design, Synthesis, Single X-Ray Crystal Structure, DFT and Molecular Docking Studies of Novel Clip Type-Pyridyltetrazole Analogues | Scopus |
| 2018 | Rana, N., Ghosh, K. S., Chand, S., Gathania, A. K. | Ind. J. Pure Appl. Phys. (Impact factor: 0.92) | Investigation of ZnO nanoparticles for their applications in wastewater treatment and antimicrobial activity | SCI (E) |
| 2017 | Sharma, V., Ghosh, K. S. | Intl. J. Biol. Macromol. (Impact factor: 6.95) | Inhibition of amyloid fibrillation and destabilization of fibrils of human ?D-crystallin by direct red 80 and orange G | SCI (E) & Scopus |
| 2017 | Chauhan, P., Velappan, A. B., Sahoo, B. K., Debnath, J., Ghosh, K. S. | J. Lumin. (Impact factor: 3.60) | Studies on molecular interactions between Schiff bases and eye lens chaperone human ?A-crystallin | SCI & Scopus |
| 2017 | Chauhan, P., Muralidharan, S. B., Velappan, A. B., Datta, D., Pratihar, S., Debnath, J., Ghosh, K. S. | J. Biol. Inorg. Chem. (Impact factor: 3.36) | Inhibition of copper-mediated aggregation of human ?D-crsytallin by Schiff bases | SCI & Scopus |
| 2016 | Sivaramakrishnan, V., Ilamathi, M., Ghosh, K. S., Sathish, S., Gowda, T. V., Vishwanath, B. S., Rangappa, K. S., Dhananjaya, B. L. | J. Mol. Recognit. (Impact factor: 2.14) | Virtual analysis of structurally diverse synthetic analogs as inhibitors of snake venom secretory phospholipase A2 | SCI & Scopus |
| 2015 | Thakur, R., Das, A., Sharma, V., Adhikari, C., Ghosh, K.S., Chakraborty, A. | Phy. Chem. Chem. Phys. (Impact factor: 3.68) | Interaction of different prototropic species of an anticancer drug Ellipticine with HSA and IgG proteins: multispectroscopic and molecular modeling studies | Web of Science |
| 2015 | Sharma, A., Ghosh, K. S., Singh, B. P., Gathania, A. K. | Methods Appl. Fluoresc. (Impact factor: 3.01) | Spectroscopic investigation of interaction between bovine gamma globulin and gold nanoparticles | SCI & Scopus |
| 2014 | Sharma, V., Ghosh, K. S. | Comp. Biol. Chem. (Impact factor: 2.88) | Involvement of non-polyalanine (polyA) residues in aggregation of polyA proteins: Clue for inhibition of aggregation | SCI & Scopus |
| 2013 | Ghosh, K. S. | Prot. Pept. Lett. (Impact factor: 1.89) | Inherent aggregation propensity of flanking residues attached to polyglutamines: implication to aggregation inhibition | SCI (E) & Scopus |
| 2013 | Roy, A. S., Ghosh, K. S., Dasgupta, S. | J. Biomol. Struct. Dyn. (Impact factor: 3.39) | An investigation into the altered binding mode of green tea polyphenols with human serum albumin on complexation with copper | SCI (E) & Scopus |
| 2012 | Roy, D., Dutta, S., Maity, S. S., Ghosh, S., Roy, A. S., Ghosh, K. S., Dasgupta, S. | J. Lumin. (Impact factor: 3.60) | Spectroscopic and docking studies of the binding of two stereoisomeric antioxidant catechins to serum albumins | SCI & Scopus |
| 2011 | Ghosh, K. S., Pande, A., Pande, J. | Biochemistry (Impact factor: 3.16) | Binding of gamma crystallin substrate prevents the binding of copper and zinc ions to the molecular chaperone alpha crystallin | SCI & Scopus |
| 2010 | Pande, A., Ghosh, K. S., Banerjee, P. R., Pande, J. | Biochemistry (Impact factor: 3.16) | Increase in surface hydrophobicity of the cataract-associated, P23T mutant of human gammaD-crystallin is responsible for its dramatically lower, retrograde solubility | SCI & Scopus |
| 2010 | Chandra, G., Ghosh, K. S., Dasgupta, S., Roy, A. | Intl. J. Biol. Macromol. (Impact factor: 6.95) | Evidence of conformational changes in adsorbed lysozyme molecule on silver colloids | SCI (E) & Scopus |
| 2010 | Mukhopadhyay, S., Maity, S. S., Roy, A., Chattopadhyay, D., Ghosh, K. S., Dasgupta, S., Ghosh, S. | Biochimie (Impact factor: 4.08) | Characterization of the structure of the phosphoprotein of chandipura virus, a negative stranded RNA virus probing intratryptophan energy transfer using single and double tryptophan mutants | SCI & Scopus |
| 2009 | Sahoo, B. K., Ghosh, K. S., Dasgupta, S. | Prot. Pept. Lett. (Impact factor: 1.89) | An Investigation of the molecular interactions of diacetylcurcumin with ribonuclease A | SCI (E) & Scopus |
| 2009 | Ghosh, K. S., Sen, S., Sahoo, B. K., Dasgupta, S. | Bioploymers (Impact factor: 2.51) | A spectroscopic investigation into the interactions of 3´-O-carboxy esters of thymidine with Bovine Serum Albumin | SCI & Scopus |
| 2009 | Sahoo, B. K., Ghosh, K. S., Dasgupta, S. | Bioploymers (Impact factor: 2.51) | Molecular interactions of isoxazolcurcumin with human serum albumin: spectroscopic and molecular modeling studies | SCI & Scopus |
| 2008 | Ghosh, K. S., Debnath, J., Pathak, T., Dasgupta, S. | Bioorg. Med. Chem. Lett. (Impact factor: 2.82) | Using Proton Nuclear Magnetic Resonance to study the mode of Ribonuclease A inhibition by competitive and noncompetitive inhibitors | SCI & Scopus |
| 2008 | Ghosh, K. S., Sahoo, B.K., Jana, D., Dasgupta, S. | J. Inorg. Biochem. (Impact factor: 4.16) | Studies on interaction of copper complexes of (-)-epicatechin gallate and (-)-epigallocatechin gallate with calf thymus DNA | SCI (E) & Scopus |
| 2008 | Sahoo, B.K., Ghosh, K. S., Dasgupta, S. | Chem. Phys. (Impact factor: 2.35) | Studies on the interaction of diacetylcurcumin with calf thymus DNA | SCI (E) & Scopus |
| 2008 | Ghosh, K. S., Debnath, J., Dutta, P., Sahoo, B. K., Dasgupta, S. | Bioorg. Med. Chem. (Impact factor: 3.64) | Exploring the potential of 3´-O-Carboxy esters of thymidine as inhibitors of ribonuclease A and angiogenin | SCI & Scopus |
| 2008 | Ghosh, K. S., Sahoo, B. K., Dasgupta, S. | Chem. Phys. Lett. (Impact factor: 2.33) | Spectrophotometric studies on the interaction between (-)-epigallocatechin gallate and lysozyme | SCI |
| 2008 | Sahoo, B. K., Ghosh, K. S., Dasgupta, S. | Biophys. Chem. (Impact factor: 2.35) | Investigating the binding of curcumin derivatives to bovine serum albumin | SCI (E) & Scopus |
| 2008 | Bera, R., Sahoo, B. K., Ghosh, K. S., Dasgupta S. (2008) | Int. J. Biol. Macromol. (Impact factor: 6.95) | Studies on the interaction of isoxazolcurcumin with calf thymus DNA | SCI (E) & Scopus |
| 2008 | Maiti, T. K., Ghosh, K. S., Samanta A., Dasgupta S. | J. Photochem. Photobiol. A (Impact factor: 4.29) | The interaction of silibinin with human serum albumin: a spectroscopic investigation | SCI & Scopus |
| 2007 | Mandal, C., Gayen, S., Basu, A., Ghosh, K. S., Dasgupta, S., Maiti, M., Sen, S. | Protein Eng. Des. Sel. (Impact factor: 1.77) | Prediction based protein engineering of domain I of Cry2A entomocidal toxin of Bacillus thuringiensis resulted enhancement of toxicity against lepidopteran insects | SCI |
| 2007 | Ghosh, K. S., Maiti, T.K., Debnath, J., Dasgupta, S. | Proteins : Structure, Functions & Bioinformatics (Impact factor: 3.76) | Inhibition of ribonuclease A by polyphenols present in green tea | SCI & Scopus |
| 2006 | Ghosh, K. S., Maiti, T.K., Mandal, A., Dasgupta, S. | FEBS Lett. (Impact factor: 4.12) | Copper complexes of (?)-epicatechin gallate and (?)-epigallocatechin gallate act as inhibitors of ribonuclease A | SCI |
| 2006 | Maiti, T. K., Ghosh, K. S., Dasgupta, S. | Proteins: Structure, Functions & Bioinformatics (Impact factor: 3.76) | Interaction of (-)-epigallocatechin-3-gallate with human serum albumin: fluorescence, fourier transform infrared, circular dichroism and docking studies | SCI & Scopus |
| 2006 | Maiti, T. K., Ghosh, K. S., Debnath, J., Dasgupta, S. | Int. J. Biol. Macromol. (Impact factor: 6.95) | Binding of all-trans retinoic acid to human serum albumin: fluorescence, FT-IR and circular dichroism studies | SCI (E) & Scopus |
| 2004 | Ghosh, K. S., Maiti, T. K., Dasgupta, S. | Biochem. Biophys. Res. Commun. (Impact factor: 3.58) | Green tea polyphenols as inhibitors of ribonuclease A | SCI & Scopus |
| 2019 | Sharma, V. and Ghosh, K. S. | Prot. Pept. Lett. (Impact factor: 1.89) | Inhibition of amyloid fibrillation by small molecules and nanomaterials: strategic development of pharmaceuticals against amyloidosis, Vol. 26, pp. 315 – 323. | SCI (E) & Scopus |
| 2019 | Chauhan, P. and Ghosh, K. S. | Spectrochim. Acta A (Impact factor: 4.10) | Inhibition of copper-induced aggregation of human gammaD-crystallin by rutin and studies on its role in molecular level for enhancing the chaperone activity of human ?A-crystallin by using multi-spectroscopic techniques, Vol. 218, pp. 229-236. | SCI & Scopus |
| 2020 | S. Rana, A. B. Velappan, J. Debnath, K. S. Ghosh | J. Biomol. Strcture Dynamics (Impact factor: 3.39) | Inhibition of copper-induced aggregation of human gammaD-crystallin by a diimine molecule and investigations on their molecular interactions | SCI (E) & Scopus |
| 2020 | S. Rana and K. S. Ghosh | Archives of Biochemistry and Biophysics (Impact factor: 4.01) | Protective role of hesperetin against posttranslational oxidation of tryptophan residue of human ?D-crystallin: A molecular level study | SCI |
| 2020 | Rana, S., K.S. Ghosh | J. Mol. Struct. (Impact factor: 3.20) | Explication of human gammaD-crystallin interactions with its aggregation inhibitor Schiff base at molecular level | SCI & Scopus |
| 2021 | Rana, S., K.S. Ghosh | J. Biomol. Strcture Dynamics (Impact factor: 3.39) | Inhibition of fibrillation of human gammaD-crystallin by a flavonoid morin | SCI (E) & Scopus |
| 2021 | Rana, S., Sarmah, S., Roy, A. S., Ghosh, K. S. | J. Biomol. Strcture Dynamics (Impact factor: 3.39) | Elucidation of molecular interactions between human gammaD-crystallin and quercetin, an inhibitor against tryptophan oxidation | SCI (E) & Scopus |
| 2020 | Sharma, V., Sharma, S., Rana, S., Ghosh, K. S. | Spectrochimica Acta A (Impact factor: 4.10) | Inhibition of amyloid fibrillation of human gammaD-crystallin by gold nanoparticles: Studies at molecular level | SCI & Scopus |
| 2020 | Sharma, A., Ghosh, K. S. | Prot. Pept. Lett. (Impact factor: 1.89) | Studies on molecular interactions between bovine beta-lactoglobulin and silver nanoparticles | SCI (E) & Scopus |
| 2020 | Velappan, A.B., Datta, D., Ma, R. Rana, S., Ghosh, K.S., Hari, N., Franzblau, S.G., Debnath, J. | Bioorg. Chem. (Impact factor: 5.28) | 2-Aryl benzazole derived new class of anti-tubercular compounds: Endowed to eradicate Mycobacterium tuberculosis in replicating and non-replicating forms | SCI |
| 2021 | S. Rana, M. Panwar, K. S. Ghosh | Coronaviruses | Docking studies with multiple molecular targets associated with SARSCoV-2 for drug repurposing | -- |
| 2021 | Sharma, S., K.S. Ghosh | Spectrochimica Acta A (Impact factor: 4.10) | Recent advances (2017-20) in the detection of copper ion by using fluorescence sensors working through transfer of photo-induced electron (PET), excited-state intramolecular proton (ESIPT) and Förster resonance energy (FRET) | SCI & Scopus |
| 2021 | Sharma, S., K.S. Ghosh | J. Mol. Struct. (Impact factor: 3.20) | Overview on recently reported fluorometric sensors for the detection of copper ion based on internal charge transfer (ICT), paramagnetic effect and aggregation induced emission (AIE) mechanisms | SCI & Scopus |
| 2021 | S. Rana, P. Kumar, A. Sharma, S. Sharma, R. Giri , K. S. Ghosh | The Open COVID Journal | Identification of naturally occurring antiviral molecules for SARS-CoV-2 mitigation | ---- |
| 2022 | A. Sharma, H. Rastogi, K. S. Ghosh | Spectrochimica Acta A (Impact factor: 4.10) | Enhancement in chaperone activity of human aA-crystallin by nanochaperone gold nanoparticles: Multispectroscopic studies on their molecular interactions | SCI & Scopus |
| 2022 | A. Sharma, S. Sarmah, A. S. Roy, K. S. Ghosh | Luminescence (Impact Factor 2.46) | Multispectroscopic studies on the molecular interactions between bovine gamma-globulin and borohydride-capped silver nanoparticles | SCI & Scopus |
Conference Publications
| Year | Author(s) | Conference | Title | Indexing |
|---|
Book/Chapters Written
| Type (Book/Chapter) | Author(s) | Title | Publisher | ISBN/ISSN No. | Year |
|---|---|---|---|---|---|
| Book Chapter | K. S. Ghosh and P. Chauhan | Crystallins and their complexes | Springer | 978-3-030-28151-9 | 2020 |
| Book Chapter | K. S. Ghosh and A. Sharma | Fluorescent nanomaterials for cellular imaging | IntechOpen | 978-1-83968-040-3 | 2020 |
Research Supersion
| Programme Name | Scholar Name | Research Topic | Status | Year | Co-Superivisor(s) |
|---|---|---|---|---|---|
| Ph.D | Priyanka Chauhan | Schiff Bases and Flavonoids as Inhibitors of Human ?D-crystallin Aggregation and their Interactions with Human ?A-crystallin: An Approach to Impede Cataract | Degree Awarded | 2013 | NIL |
| Ph.D | Vandna Sharma | Studies on Fibrillation of Human gammaD-Crystallin and its Inhibition by using Small Molecules and Nanoparticles | Degree Awarded | 2014 | NIL |
| Ph.D | Shiwani Rana | Inhibition of posttranslational modifications and amyloid fibrillation of human gammaD-crystallin | Degree Awarded | 2016 | NIL |
| Ph.D | Anchal Sharma | Inhibition of protein fibrillation by nanomaterails and studies on interactions between biomacromolecules and nanomaterials | Thesis Submitted | 2017 | NIL |
| Ph.D | Shivani Sharma | Synthesis & development of fluorescence sensors for detection of cations | In progress (State of Art completed) | 2018 | NIL |
| M.Tech | Sristhi Verma (M.Sc.) | Protein chemistry | Completed | 2019 | NIL |
| M.Tech | Sheetal (M.Sc.) | Protein chemistry | Completed | 2019 | NIL |
| M.Tech | Subham Sharma (M.Sc) | Bionanochemistry | Completed | 2019 | NIL |
| M.Tech | Arvind (M.Sc) | Bionanochemistry | Completed | 2019 | NIL |
| M.Tech | Sakshi (M.Sc.) | Synthesis & development of metal sensors | Completed | 2020 | NIL |
| M.Tech | Neha (M.Sc.) | Synthesis & development of metal sensors | Completed | 2020 | NIL |
| M.Tech | Yogesh Routela (M.Sc.) | Synthesis of Schiff base molecules | Completed | 2021 | NIL |
| M.Tech | Abhijit Bhagat (M.Sc.) | Synthesis of Schiff base molecules | Completed | 2021 | NIL |
| M.Tech | Meghali (M.Sc.) | Synthesis of Schiff base molecules | Completed | 2021 | NIL |
| M.Tech | Shivanand (M.Sc.) | Synthesis of Schiff base molecules | Completed | 2021 | NIL |
| M.Tech | Divya Yadav (M.Sc.) | Synthesis of Schiff base sensor | Ongoing | 2022 | NIL |
| M.Tech | Adarsh Porwal (M.Sc.) | Development of metal ion sensor | Ongoing | 2022 | NIL |
| M.Tech | Sachin Kumar (M.Sc.) | Development of metal ion sensor | Ongoing | 2022 | NIL |
| M.Tech | Saurin Maity (M.Sc.) | Design and development of nanosensor | Ongoing | 2022 | NIL |
| Ph.D | Sushma | Design and development of nanomaterials in sensing applications | Ongoing | 2021 | NIL |
| Ph.D | Ankita Sharma | Design & Development of ion sensors | Ongoing | 2022 | NIL |
Patents
| Name | Reg./Ref.No. | Date of Award/Filling | Awarding Agencies | Status |
|---|
Conferences/Workshop/Courses Organized
| Category | Type | Title | Venue | From | To | Designation |
|---|---|---|---|---|---|---|
| conference | National | Recent Trends in Chemical Sciences, Engineering and Technology (RTCET 2014) | NIT Hamirpur | 29/05/2014 | 30/05/2014 | Co-Convener |
| stc | GIAN Course | Advanced Nanomaterials: Applications in Disease Diagnosis and Imaging | NIT Hamirpur | 30/05/2016 | 03/06/2016 | Coordinator |
| stc | GIAN Course | Chemical, Biochemical and Environmental Issues Related to Cancer and Solutions Addressing Problems | NIT Hamirpur | 11/09/2017 | 16/09/2017 | Coordinator |
| conference | National | Recent Trends in Chemical Sciences & Engineering (RTCSE - 2017) | NIT Hamirpur | 13/10/2017 | 14/10/2017 | Organizing Secretary |
| workshop | National | Recent Advances in Characterization of Multi-functional Materials | NIT Hamirpur | 17/02/2020 | 22/02/2020 | Convener |
Expert Talks
| Title | Place | Year | Description of Event |
|---|---|---|---|
| Invited Talk | Indira Gandhi National Tribal University, Amarkantak (A Central University) | 2015 | National Workshop cum Seminar on “Frontiers in Ethnomedicinal Research” |
Consultancy
| Title of Consultancy | Client Organization | Faculty Involved | Amount(INR) | Status |
|---|
International and National Exposure
| Sr.No. | Title | Description |
|---|---|---|
| 1 | Postdoctoral Associate/Postdoctoral Associate | State University of New York, Albany /University of Maryland, College Park |
Honors & Recognitions Achieved
| Sr.No. | Title | Activity | Given By | Year |
|---|